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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Relationship of carotid arterial functional and structural changes to left atrial volume in untreated hypertension

Joanna Jaroch, Barbara Rzyczkowska, Zbigniew Bociąga

    Acta Cardiologica
    |April 20, 2016
    PubMed

    Insights

    Arterial stiffness, not intima-media thickness, is linked to left atrial volume in hypertension patients. This finding highlights the importance of arterial stiffness in assessing diastolic burden in untreated hypertension.

    Area of Science:

    • Cardiovascular Medicine
    • Hypertension Research
    • Echocardiography

    Background:

    • Arterial stiffness and structural changes contribute to left ventricular diastolic dysfunction.
    • Left atrial remodeling serves as a marker of diastolic burden.
    • The association between arterial structure and left atrial remodeling in hypertension is not well understood.

    Purpose of the Study:

    • To investigate the relationship between carotid arterial stiffness (a.s.) and intima-media thickness (IMT) and left atrial (LA) volume in hypertensive subjects.
    • To identify determinants of LA volume in untreated hypertension.

    Main Methods:

    • Study included 245 untreated hypertensive patients.
    • Echocardiography was used to measure LA volume, left ventricular hypertrophy (LVH), and systolic/diastolic function.
    • Carotid IMT and echo-tracking assessed arterial stiffness and wave reflection parameters.

    Main Results:

    • Indexed LA volume correlated with clinical characteristics, LVH, LV function, and arterial stiffness parameters.
    • Independent determinants of indexed LA volume included diastolic blood pressure, left ventricular mass index (LVMI), E/e’ index, augmentation index (AI), and body mass index (BMI).
    • No correlation was found between indexed LA volume and IMT.

    Conclusions:

    • Carotid arterial stiffness, but not IMT, is significantly related to LA volume in patients with untreated hypertension.
    • Arterial stiffness is a significant determinant of left atrial remodeling in hypertension.

    Keywords:
    Arterial stiffnessIMTleft atrial volume

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