Related Experiment Video

Updated: Mar 22, 2026

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

21.1K

Chemerin as an independent predictor of cardiovascular event risk

Sinan İnci1, Gökhan Aksan2, Pınar Doğan3

  • 1Departmant of Cardiology, Aksaray State Hospital, Zafer mah.Nevşehir cad. no:117, Aksaray/Merkez, Turkey.

Therapeutic Advances in Endocrinology and Metabolism
|April 20, 2016
PubMed

Insights

Chemerin, an adipokine linked to inflammation, shows elevated levels in coronary artery disease (CAD). Further research is needed to fully understand chemerin's role in cardiovascular disease development and progression.

Area of Science:

  • Biochemistry
  • Cardiology
  • Endocrinology

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide, associated with various risk factors.
  • Chemerin, a novel adipokine, is implicated in inflammation and adipogenesis, with elevated levels observed in metabolic and inflammatory conditions.
  • Increased serum chemerin levels are recognized as a marker for CAD, but its comprehensive role remains under investigation.

Purpose of the Study:

  • To review the expression, processing, biological functions, and disease relevance of chemerin.
  • To elucidate the specific role of chemerin in the pathogenesis and maintenance of cardiovascular disease.

Main Methods:

  • Literature review of experimental and clinical data on chemerin.
  • Analysis of studies investigating chemerin levels in various inflammatory and metabolic diseases, including cardiovascular disease.
  • Synthesis of current knowledge on chemerin's involvement in cardiovascular disease.

Main Results:

  • Chemerin expression and activation are elevated in numerous metabolic and inflammatory diseases.
  • Serum chemerin levels are significantly increased in patients with coronary artery disease.
  • Chemerin is recognized as a potential biomarker for CAD, though its full characteristics require further exploration.

Conclusions:

  • Chemerin plays a significant role in the development and progression of cardiovascular disease.
  • Understanding chemerin's multifaceted functions is crucial for advancing cardiovascular disease research.
  • Further investigation into chemerin's mechanisms is warranted to explore its therapeutic potential.

Keywords:
cardiovascular diseasechemerinmarker

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.9K
Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

762

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
733
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
653
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.6K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
837
Hazard Ratio01:12

Hazard Ratio

The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
688
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
767