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Related Concept Videos

Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Chemotherapy and Targeted Therapy.

Mehmet Sen, Robin Prestwich

    Advances in Oto-Rhino-Laryngology
    |April 20, 2016
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    Summary
    This summary is machine-generated.

    Salivary gland cancers are rare head and neck tumors. Research is exploring targeted therapies based on molecular signatures due to limited success with chemotherapy in metastatic disease.

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    Area of Science:

    • Oncology
    • Head and Neck Cancer Research
    • Molecular Biology

    Background:

    • Salivary gland cancers are uncommon head and neck neoplasms with significant diversity.
    • Limited prospective data exists for non-surgical treatments due to this heterogeneity.
    • Chemotherapy shows minimal efficacy in metastatic disease and is rarely used definitively.

    Purpose of the Study:

    • To review the current landscape of non-surgical treatments for salivary gland cancers.
    • To highlight the emerging role of molecularly targeted therapies.
    • To address the paucity of data on systemic therapy in definitive management.

    Main Methods:

    • Literature review focusing on non-surgical and systemic treatments.
    • Analysis of recent research on molecular signatures and genomic alterations.
    • Investigation of identified signaling pathways and targeted therapy investigations.

    Main Results:

    • Chemotherapy has demonstrated limited activity in metastatic salivary gland cancers.
    • Systemic therapy lacks standard recommendations, with palliative use on a case-by-case basis.
    • Molecular profiling has identified key signaling pathways in various subtypes.

    Conclusions:

    • Targeted therapies are being investigated based on identified molecular pathways.
    • Further research is needed to establish effective systemic treatment strategies.
    • Personalized medicine approaches hold promise for salivary gland cancer management.