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Related Experiment Video

Updated: Mar 22, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Lethal Dengue Virus Infection: A Forensic Overview.

Roger W Byard¹

¹From the Discipline of Anatomy and Pathology, University of Adelaide, Adelaide, South Australia, Australia.

The American Journal of Forensic Medicine and Pathology

|April 20, 2016

Summary

This summary is machine-generated.

Dengue virus, a flavivirus transmitted by Aedes mosquitoes, causes severe illness. This review highlights clinicopathological features and emphasizes autopsy sampling for accurate diagnosis of dengue infections.

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Area of Science:

Virology
Infectious Diseases
Public Health

Background:

Dengue virus (family Flaviviridae, genus Flavivirus) is a single-stranded RNA virus.
Transmitted by Aedes aegypti mosquitoes, it causes dengue fever, potentially progressing to severe dengue hemorrhagic fever or dengue shock syndrome.
Untreated dengue shock syndrome has a mortality rate exceeding 20%.

Purpose of the Study:

To review the clinicopathological features of dengue viral infection.
To address diagnostic challenges in forensic settings due to dengue's varied manifestations.
To underscore the importance of proper autopsy sampling for microbiological identification.

Main Methods:

Literature review of clinicopathological features of dengue.
Evaluation of diagnostic challenges in forensic mortuaries.
Emphasis on autopsy procedures for viral identification.

Main Results:

Dengue incidence has surged 30-fold in 50 years, causing 50-100 million infections and 22,000 deaths annually.
Forensic cases are increasing, presenting diagnostic difficulties.
Clinicopathological findings are crucial for understanding disease progression.

Conclusions:

Accurate microbiological identification and characterization of dengue virus are essential.
Adequate blood and tissue sampling during autopsy are mandatory for diagnosis.
Understanding clinicopathological features aids in managing and diagnosing dengue cases.