CYCLOPHOSPHAMIDE TREATMENT ALTERS THE CONTRACTILITY OF ISOLATED RAT VAS DEFERENS

Influence of cyclophosphamide treatment (40. mg/kg, ip on alternate days for 5 times) was assessed on 1 m mol BaCl2-induced in vitro rhythmic contractions in isolated rat vas deferens. The mean frequency (contractions per min) and amplitude (g tension) of rhythmic contractions were significantly decreased in the tissues isolated from cyclophosphamide-treated rats as compared to the control tissues. These findings indicate a decrease in the contractility and, therefore, functioning of rat vas deferens under cyclophosphamide therapy.