Related Experiment Video
Updated: Mar 22, 2026

Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker
Published on: December 18, 2014
NORADRENERGIC MECHANISMS IN THE PROCONVULSANT EFFECTS OF BUSPIRONE
1Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062.
Abstract:
The effect of buspirone on the protection of chemically and electrically-induced seizures by anticonvulsant drugs was studied in mice. We found antagonism to the protective action of sodium valproate (300 mg/kg, po), carbamazepine (420 mg/kg, po) and phenytoin (23.2 mg/kg, po) against picrotoxin (3.5 mg/kg, ip) and maximal electroshock (54 mA, 0.2s) induced seizures by BUS (20 mg/kg, po) and a reversal of such antagonism by pretreatment with clonidine (1 mg/kg, po). The effects appear to be elicited through central α2 adrenoceptor mechanisms.
Related Concept Videos
Anxiolytic Drugs: Benzodiazepines and Buspirone
Anxiolytic Drugs: Overview
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
Drugs Affecting Neurotransmitter Release or Uptake
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
CNS Depressants: Barbiturates and Benzodiazepines
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions
Although all competitive neuromuscular blockers are designed...

