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Related Concept Videos

Spinal Cord: Cross-sectional Anatomy01:16

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The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
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Related Experiment Video

Updated: Mar 22, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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The role of global and regional gray matter volume decrease in multiple sclerosis.

Matthias Grothe1, Martin Lotze2, Sönke Langner3

  • 1Department of Neurology, University Medicine of Greifswald, Greifswald, Germany. matthias.grothe@uni-greifswald.de.

Journal of Neurology
|April 21, 2016
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) patients

Keywords:
EDSSGray matter atrophyMultiple sclerosisVoxel-based morphometry

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Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Disability in multiple sclerosis (MS) is linked to white matter (WM) and gray matter (GM) damage.
  • Gray matter volume loss can be quantified using voxel-based morphometry (VBM).

Purpose of the Study:

  • To investigate the relationship between increasing disability and decreasing total and regional gray matter volume in MS patients.
  • To compare gray matter changes between relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS) patients.

Main Methods:

  • Retrospective analysis of 213 MS patients (163 RRMS, 50 SPMS).
  • Utilized semi-automated WM lesion mapping and VBM to assess GM volume.
  • Disability was measured using the Expanded Disability Status Scale (EDSS).

Main Results:

  • Total GM volume and WM lesion load correlated with patient disability (EDSS).
  • Regional GM volume loss in the cerebellum was associated with higher EDSS scores and WM lesion volume.
  • SPMS patients exhibited greater GM volume loss in the cerebellum and hippocampus compared to RRMS patients.

Conclusions:

  • Cerebellar and hippocampal gray matter atrophy significantly contribute to disability in MS.
  • These findings underscore the critical roles of the cerebellum and hippocampus in MS pathogenesis and progression.