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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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The human body is a complex, well-organized machine, and at the heart of its operations lies the circulatory system. This network of blood vessels, which includes systemic arteries, plays a vital role in maintaining life by transporting nutrients, oxygen, and waste products to and from cells throughout the body.
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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Related Experiment Video

Updated: Mar 22, 2026

Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm
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Severe Arterial Tortuosity.

Alain Cubero1, Javier Ayala2, Gadah Hamzeh1

  • 11 Division of Cardiac Surgery, Cruces University Hospital, Barakaldo, Spain.

World Journal for Pediatric & Congenital Heart Surgery
|April 21, 2016
PubMed
Summary

Arterial tortuosity syndrome, a rare connective tissue disease, involves complex artery abnormalities. This study details three severe cases, highlighting diverse manifestations and surgical interventions for aortic arch and pulmonary artery involvement.

Keywords:
CHDaortic archgeneticspulmonary arteriesvascular disease

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Area of Science:

  • Cardiology
  • Genetics
  • Vascular Surgery

Background:

  • Arterial tortuosity syndrome (ATS) is a rare, autosomal recessive disorder.
  • It is characterized by elongated, tortuous, and aneurysmal arteries.
  • Associated conditions include pulmonary artery and/or aortic stenosis.

Purpose of the Study:

  • To present three distinct cases of severe arterial tortuosity syndrome.
  • To illustrate varied clinical manifestations and anatomical involvements.
  • To discuss surgical management strategies for complex cases.

Main Methods:

  • Case series presentation.
  • Diagnostic imaging including angiography.
  • Surgical intervention and repair.

Main Results:

  • Two cases involved the aortic arch with significant tortuosity; one required surgical repair.
  • The third case presented with severe, multiple pulmonary artery stenoses and tortuous segments.
  • Pulmonary artery augmentation using a bovine pericardial patch was successfully performed.

Conclusions:

  • Severe arterial tortuosity syndrome presents with diverse vascular complications.
  • Surgical intervention can be effective for managing complex aortic arch and pulmonary artery abnormalities in ATS.
  • Further research into ATS management is warranted.