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Renal Transplantation in Advanced Chronic Kidney Disease Patients
1Department of Medicine, Lewis Katz School of Medicine at Temple University, 3440 N Broad St, Kresge West Suite 100, Philadelphia, PA 19046, USA.
Abstract:
Kidney transplantation is the best option for patients with end-stage kidney disease. It is associated with better quality of life, lower medical costs, less hospitalization, and improved survival compared with wait-listed patients who remain on dialysis. Timely referral for transplantation is essential to reap the maximal benefit and should begin in the advanced chronic kidney disease stage prior to starting dialysis. Shortage of donor organs remains the biggest challenge to transplantation. With the improved success of kidney transplantation, candidate acceptance criteria continue to broaden. This article provides an overview of the pretransplantation multidisciplinary evaluation process detailing the factors that determine transplant candidacy.
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Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...

