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Related Concept Videos

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Introduction to Connective Tissues01:11

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Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
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Pericarditis I: Introduction01:22

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Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
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Vascular Spasm01:16

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The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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Connective Tissue Disorder-Associated Vasculitis.

Aman Sharma1, Aadhaar Dhooria2, Ashish Aggarwal2

  • 1Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 160012. amansharma74@yahoo.com.

Current Rheumatology Reports
|April 22, 2016
PubMed
Summary
This summary is machine-generated.

Secondary vasculitis, linked to connective tissue diseases, can impact any vessel size and organ system, often indicating a poor prognosis. This review highlights recent advances in managing these complex conditions.

Keywords:
CTD-associated vasculitisLupus vasculitisRheumatoid vasculitisSarcoid vasculitisSecondary vasculitisSystemic sclerosis-associated vasculitis

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Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Vasculitides secondary to connective tissue diseases are categorized under 'vasculitis associated with systemic disease' by the International Chapel Hill Consensus Conference (CHCC).
  • These conditions can affect small, medium, or large vessels, potentially leading to a poor prognosis.
  • Organ system involvement is variable, influencing clinical presentation.

Purpose of the Study:

  • To review recent advances in understanding and managing secondary vasculitides associated with specific connective tissue diseases.
  • To focus on developments within the past three years.

Main Methods:

  • Literature review of recent scientific publications.
  • Synthesis of information on vasculitis associated with rheumatoid arthritis, systemic lupus erythematosus, sarcoidosis, relapsing polychondritis, systemic sclerosis, Sjogren's syndrome, and idiopathic inflammatory myositis.

Main Results:

  • Secondary vasculitides present a diverse clinical spectrum depending on the underlying disease and affected organs.
  • Treatment strategies are tailored to the specific type and severity of the vasculitic presentation.
  • Recent advances have improved diagnostic and therapeutic approaches for these complex conditions.

Conclusions:

  • Vasculitis secondary to connective tissue diseases represents a significant clinical challenge with variable manifestations and prognoses.
  • Effective management requires a comprehensive understanding of the underlying systemic disease and the vasculitic process.
  • Ongoing research continues to refine treatment paradigms for improved patient outcomes.