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Clinical experience with ciprofloxacin: analysis of a multi-practice study
Journal of the South Carolina Medical Association (1975)
|March 1, 1989
Summary
Ciprofloxacin demonstrated high efficacy in treating various infections, achieving over 97% clinical cure or improvement rates. Adverse reactions were infrequent, with most patients tolerating the antibiotic well.
Area of Science:
- Infectious Diseases
- Pharmacology
Background:
- Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic.
- Its efficacy and safety profile require ongoing evaluation across diverse patient populations and infection types.
Purpose of the Study:
- To assess the clinical and bacteriologic outcomes of ciprofloxacin treatment for various infections.
- To evaluate the incidence and nature of adverse drug reactions (ADRs) associated with ciprofloxacin therapy.
Main Methods:
- A multi-practice study involving 113 patients treated with ciprofloxacin.
- Dosage: mean 995 mg/day; Duration: mean 9.6 days.
- Infections included microbiologically proven and chronic cases.
Main Results:
- High rates of bacteriologic cure/improvement (92.9%) and clinical cure/improvement (97.1%) were observed.
- Ciprofloxacin was discontinued due to adverse effects in only 2.6% of patients.
- Overall ADR incidence was 4.4%, with only one definitely related to ciprofloxacin.
Conclusions:
- Ciprofloxacin is highly effective for a range of infections, demonstrating excellent clinical and bacteriologic outcomes.
- The antibiotic exhibits a favorable safety profile with a low incidence of significant adverse drug reactions.
- Ciprofloxacin represents a valuable therapeutic option for managing bacterial infections.