Related Experiment Video

Updated: Mar 22, 2026

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

28.0K

Antimicrobial Resistance of Acinetobacter baumannii to Imipenem in Iran: A Systematic Review and Meta-Analysis

Maryam Pourhajibagher1, Farhad B Hashemi1, Babak Pourakbari2

  • 1Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

The Open Microbiology Journal
|April 22, 2016
PubMed

Insights

Imipenem-resistant multi-drug resistant Acinetobacter baumannii is a growing global threat. A meta-analysis found 55% of A. baumannii resistant to imipenem and 74% multi-drug resistant in Iran.

Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Acinetobacter baumannii is a significant nosocomial pathogen worldwide.
  • Imipenem resistance is a critical concern for treating A. baumannii infections.
  • Multi-drug resistance (MDR) complicates treatment options.

Purpose of the Study:

  • To systematically review and meta-analyze the prevalence of imipenem-resistant MDR A. baumannii in Iran.
  • To assess the current status of antibiotic resistance in A. baumannii isolates.

Main Methods:

  • Systematic literature search across major scientific databases (Web of Science, PubMed, EMBASE, Scopus, etc.) and Iranian databases.
  • Inclusion and exclusion criteria applied to 58 initial articles, with 51 selected for analysis.
  • Meta-analysis to determine pooled prevalence rates of imipenem resistance and MDR.

Main Results:

  • 55% of A. baumannii isolates showed resistance to imipenem (95% CI, 53.0-56.5).
  • 74% of A. baumannii isolates were identified as MDR (95% CI, 61.3-83.9).
  • A significant trend towards increasing imipenem resistance in MDR A. baumannii populations in Iran was observed.

Conclusions:

  • High prevalence of imipenem-resistant MDR A. baumannii necessitates urgent attention.
  • Findings underscore the critical need for enhanced infection control policies and national surveillance programs in Iran.
  • Regular susceptibility reviews are essential to monitor and combat emerging resistance patterns.
Keywords:
Acinetobacter baumanniiIranimipeneminfectionmulti-drug resistantnosocomial

More Related Videos

Author Spotlight: A Comprehensive Protocol for Acinetobacter Biofilm Quantification, Assessment, and Visualization07:41

Author Spotlight: A Comprehensive Protocol for Acinetobacter Biofilm Quantification, Assessment, and Visualization

Published on: August 4, 2023

4.6K
Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System05:06

Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

1.2K

Related Concept Videos

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.8K
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
44
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
10
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.9K