A method for direct in vivo measurement of drug concentrations from a single 2H NMR spectrum
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J L Evelhoch1, C L McCoy, B P Giri
1Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201.
Magnetic Resonance in Medicine
|March 1, 1989
Abstract:
The use of 2H-labeled drugs provides a measure of drug concentration in situ directly from a single 2H NMR spectrum obtained with any antenna by correcting only for differential saturation effects. The limit of detection for a drug labeled with three equivalent deuterons is roughly 0.5 mM.