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Effect of Pseudoexfoliation on Corneal Transparency
Ali Bulent Cankaya1, Kemal Tekin, Merve Inanc
1*Department of Ophthalmology, Hacettepe University, Faculty of Medicine, Ankara, Turkey; and †Ophthalmology Clinic, Ulucanlar Eye Research Hospital, Ankara, Turkey.
Cornea
|April 22, 2016
Summary
Pseudoexfoliation syndrome (PES) reduces corneal transparency. This study found higher corneal optical density (COD) in eyes with PES and unaffected fellow eyes compared to healthy controls, indicating reduced clarity.
Area of Science:
- Ophthalmology
- Corneal Imaging
- Ocular Surface Disease
Background:
- Pseudoexfoliation syndrome (PES) is a common condition affecting ocular tissues.
- Corneal optical density (COD) is a measure of corneal transparency.
Purpose of the Study:
- To compare corneal optical density (COD) parameters in eyes with pseudoexfoliation syndrome (PES) and age-matched controls.
- To investigate the effect of pseudoexfoliation material on corneal transparency.
Main Methods:
- Prospective, cross-sectional study design.
- Utilized Pentacam HR-Scheimpflug imaging to measure COD.
- Included 42 patients with unilateral PES and 40 healthy controls.
Main Results:
- No significant difference in central corneal thickness between groups.
- Mean total COD was significantly higher in PES eyes (21.9 ± 4.9) and unaffected fellow eyes (21.95 ± 5.1) compared to controls (17.72 ± 4.7).
- Indicates reduced corneal transparency in eyes affected by or at risk of PES.
Conclusions:
- Pseudoexfoliation material presence decreases clear cornea transparency.
- Corneal optical density is a potential biomarker for assessing corneal health in PES.
