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Increased erythrocyte aggregation in patients with primary open angle glaucoma.

Emine Kilic-Toprak1,2, Ibrahim Toprak3, Ozgen Kilic-Erkek4

  • 1Department of Physiotherapy, Denizli Health Services Vocational High School, Pamukkale University, Denizli, Turkey. pt_emine@yahoo.com.

Clinical & Experimental Optometry
|April 23, 2016
PubMed
Summary

Primary open-angle glaucoma (POAG) patients show higher erythrocyte aggregation. This blood rheology change may impact optic nerve head microperfusion, suggesting potential therapeutic targets for glaucoma management.

Keywords:
erythrocyte aggregationoptic nerve headoptical coherence tomographyprimary open angle glaucomared blood cell deformability

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Area of Science:

  • Ophthalmology
  • Hematology
  • Biomedical Engineering

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Understanding the role of blood rheology in POAG pathogenesis is crucial for developing new treatments.
  • Alterations in erythrocyte aggregation and deformability may contribute to optic nerve damage in POAG.

Purpose of the Study:

  • To investigate alterations in blood rheology, specifically erythrocyte aggregation and deformability, in POAG patients.
  • To explore the relationship between rheological parameters and structural measurements from optical coherence tomography (OCT) in different stages of POAG.

Main Methods:

  • Prospective controlled study involving 23 POAG patients and 23 healthy controls.
  • Erythrocyte aggregation and elongation index (EI) for erythrocyte deformability were measured using an ektacytometer.
  • Optic nerve head (ONH) morphology and peripapillary retinal nerve fibre layer (RNFL) thickness were assessed using spectral domain (SD) OCT.

Main Results:

  • No significant differences in erythrocyte deformability (EI) were observed between POAG patients and controls.
  • Erythrocyte aggregation amplitude (AMP) and mean corpuscular haemoglobin concentration (MCHC) were significantly higher in the POAG group.
  • A significant correlation was found between EI and RNFL thickness in late-stage glaucoma patients.

Conclusions:

  • Erythrocyte aggregation is elevated in patients with POAG.
  • Altered rheological properties, particularly increased erythrocyte aggregation, may play a role in POAG pathogenesis by affecting ocular microperfusion.
  • Modulating rheological parameters could be a potential adjuvant therapy for glaucoma management, warranting further investigation in larger cohorts.