Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

679
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
679
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

739
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
739
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

310
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
310
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

547
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
547
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

314
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
314
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

1.0K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Apolipoprotein L1 (APOL1) and Nephropathy.

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2026
Same author

Infectious Complications and Prognostic Factors of Mortality in Patients with Lupus Nephritis Admitted to Intensive Care Units.

Journal of clinical medicine·2025
Same author

Lymphoid Peritoneal Fluid as a Variant of Chylous-Like Effluent in Peritoneal Dialysis: Proposal for a New Diagnostic Term.

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2025
Same author

Clinical and Immunological Factors Associated with the Progression of Lupus Nephritis in a Population from the Colombian Caribbean.

Biomedicines·2024
Same author

Renal Functional Reserve in Naïve HIV Patients.

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2024
Same author

Hereditary Amyloidosis: Insights Into a Fibrinogen A Variant Protein.

Proteins·2024

Related Experiment Video

Updated: Mar 22, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

17.2K

Aging Kidney Transplantation.

Carlos G Musso1,2, María C Giordani1, Nora Imperiali1

  • 1Nephrology Division, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion
|April 23, 2016
PubMed
Summary
This summary is machine-generated.

Kidney transplant senescence, characterized by cellular aging and increased immunogenicity, contributes to graft deterioration and loss. Understanding this process is key for nephrologists to improve long-term kidney transplant survival.

More Related Videos

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

21.9K
Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol
11:47

Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol

Published on: February 21, 2016

12.7K

Related Experiment Videos

Last Updated: Mar 22, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

17.2K
Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

21.9K
Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol
11:47

Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol

Published on: February 21, 2016

12.7K

Area of Science:

  • Immunology
  • Nephrology
  • Gerontology

Background:

  • Renal graft deterioration involves immunological and non-immunological factors.
  • Histological lesions in aging kidneys, like fibrosis and atrophy, are also seen in transplanted kidneys.
  • Kidney transplant senescence is proposed as a contributor to graft loss.

Purpose of the Study:

  • To explore the concept of kidney transplant senescence.
  • To understand the mechanisms and implications of senescence in renal grafts.
  • To highlight the role of senescence in graft deterioration and loss.

Main Methods:

  • Review of existing literature on kidney transplant senescence.
  • Analysis of cellular and immunological markers associated with aging and senescence.
  • Examination of histological findings in aging and transplanted kidneys.

Main Results:

  • Kidney transplant senescence shares characteristics with natural aging, including gene expression changes, telomere shortening, and mitochondrial alterations.
  • Tubular frailty in aged kidneys increases susceptibility to injury and inflammation.
  • Renal tissue injury in older grafts can lead to hyperfiltration and increased immunogenicity, triggering rejection.

Conclusions:

  • Kidney transplant senescence is a multifaceted process contributing to graft loss.
  • Recognizing and managing senescence is crucial for nephrologists to enhance graft survival.
  • Further research into renal graft senescence will aid in optimizing transplant outcomes.