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Reduction in mean platelet volume in children with acute bronchiolitis
Ayşe Betül Ergül1, Yasemin Altuner Torun2, Salih Uytun1
1Clinic of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
Insights
Mean platelet volume is lower in children with acute bronchiolitis. This finding suggests platelet indices may aid in diagnosing pediatric inflammatory conditions like bronchiolitis.
Area of Science:
- Pediatric Hematology
- Inflammatory Diseases
- Respiratory Infections
Background:
- Platelets play a role in inflammation and alter shape upon activation.
- Changes in platelet volume indices, such as mean platelet volume (MPV) and platelet distribution width (PDW), reflect platelet activation.
- MPV and PDW are considered potential biomarkers for inflammatory conditions.
Purpose of the Study:
- To investigate platelet volume indices in children diagnosed with acute bronchiolitis.
- To assess the diagnostic and prognostic value of MPV and PDW in pediatric acute bronchiolitis.
Main Methods:
- A cohort of 514 infants under 2 years old was analyzed.
- Study groups included 313 infants with acute bronchiolitis (mild, moderate, severe) and 201 healthy controls.
- MPV and PDW values were compared across groups using statistical analysis with a significance level of p<0.05.
Main Results:
- Mean platelet volume (MPV) was significantly lower in all acute bronchiolitis groups (mild, moderate, severe) compared to the control group (p=0.000).
- Platelet distribution width (PDW) showed no statistically significant difference between bronchiolitis groups and controls (p=0.159).
- Platelet count was significantly higher in infants with acute bronchiolitis compared to controls (p=0.000).
Conclusions:
- Mean platelet volume is decreased in children with acute bronchiolitis.
- MPV is not a reliable indicator for determining the severity of acute bronchiolitis.
- Clinicians should consider interpreting MPV values in hemogram results for pediatric patients with suspected inflammation.
Aim:
Platelets which are known to play a role in inflamation change their shapes when they are activated and this change is reflected in mean platelet volume and platelet distribution width values. Therefore, the mean platelet volume and platelet distribution width values are considered to be beneficial parameters for the diagnosis and treatment of many inflammatory diseases. The aim of the study was to evaluate platelet volume indices in children with acute bronchiolitis.
Material And Methods:
A total of 514 infants who were below the age of 2 years old were evaluated in this study. Three hundred thirteen of these infants were diagnosed with acute bronchiolitis patients and 201 were healthy children. The patients were separated into four groups as mild, moderate, severe bronchiolitis and the control patient group. The groups were evaluated in terms of significant differences in the values of mean platelet volume and platelet distribution width. A p value of <0.05 was considered statistically significant for all results.
Results:
The mean platelet volume was found to be 6.8±0.6 fL in the patients with mild bronchiolitis attack, 6.7±0.6 fL in the patients with moderate bronchiolitis attack, 6.5±0.5 fL in the patients with severe bronchiolitis attack and 7.3±1.1 fL in the control group. The mean platalet volume was statistically significantly lower in the mild, moderate and severe bronchiolitis attack groups compared to the control group (p=0.000). The platelet distribution width was found to be 17.2%±0.83 in the mild bronchiolitis attack group, 17.1%±0.96 in the moderate bronchiolitis attack group, 17.3%±0.87 in the severe bronchiolitis attack group and 16.9±1.6% in the control patient group. This difference was not statistically significant (p=0.159). The platelet count was statistically significantly higher in the mild, moderate and severe bronchiolitis attack groups compared to the control group (p=0.000).
Conclusions:
The mean platalet volume is decreased in patients with acute bronchiolitis. It is not a useful criterion in determining the severity of bronchiolitis attack. It is important that clinicians evaluating hemogram results to also interprete this variable.
