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Updated: Mar 22, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Dynamic Optical Coherence Tomography in Dermatology.

Martina Ulrich1, Lotte Themstrup, Nathalie de Carvalho

  • 1CMB Collegium Medicum Berlin, Berlin, Germany.

Dermatology (Basel, Switzerland)
|April 23, 2016
PubMed
Summary
This summary is machine-generated.

Dynamic optical coherence tomography (D-OCT) visualizes microvasculature in skin lesions, enhancing diagnosis of skin cancers like basal cell carcinoma and melanoma. This functional imaging offers valuable data for clinical and scientific applications.

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Area of Science:

  • Dermatology
  • Medical Imaging
  • Oncology

Background:

  • Optical coherence tomography (OCT) is a non-invasive imaging technique with potential in diagnosing non-melanoma skin cancer.
  • Recent advancements have improved OCT's diagnostic accuracy for basal cell carcinoma.
  • Ongoing technical developments are expanding OCT's use for various neoplastic and inflammatory skin diseases.

Purpose of the Study:

  • To review literature and preliminary data on dynamic OCT (D-OCT) for microvasculature visualization in skin lesions.
  • To assess the potential of D-OCT for future scientific and clinical studies in dermatology and oncology.
  • To present an atlas of D-OCT findings in skin cancers and other skin diseases.

Main Methods:

  • Literature review and analysis of preliminary unpublished data.
  • Focus on dynamic OCT (D-OCT), a technique based on speckle variance OCT.
  • In vivo evaluation of blood vessel distribution within specific skin lesions.

Main Results:

  • D-OCT enables in vivo evaluation of microvasculature in skin lesions, providing functional information.
  • The technique offers a greater density of data compared to traditional OCT.
  • An atlas of D-OCT findings in skin cancers (including melanoma) and other skin diseases is presented.

Conclusions:

  • Dynamic OCT shows promise for enhanced visualization of microvasculature in various skin diseases.
  • The functional information provided by D-OCT can aid in the diagnosis of skin cancers.
  • Further validation is required to establish definitive diagnostic features for D-OCT in clinical practice.