Related Experiment Video

Updated: Mar 22, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

10.4K

Adenoviral vector-based strategies against infectious disease and cancer

Chao Zhang1, Dongming Zhou1

  • 1a Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences , Shanghai , China.

Human Vaccines & Immunotherapeutics
|April 23, 2016
PubMed

Insights

Adenoviral vectors are powerful tools for vaccines and cancer therapy. This review covers their characteristics, applications, and strategies to overcome immune barriers for improved efficacy.

Area of Science:

  • Virology
  • Immunology
  • Biotechnology

Background:

  • Adenoviruses (Ads) are versatile viral vectors utilized in medicine.
  • They serve as vaccine carriers eliciting immune responses and as agents for cancer therapy inducing apoptosis.
  • Pre-existing neutralizing antibodies can limit the effectiveness of Ad-based strategies.

Purpose of the Study:

  • To review the biological characteristics of adenoviruses.
  • To summarize the latest developments in Ad vector-based strategies for infectious diseases and cancers.
  • To discuss methods for overcoming pre-existing neutralizing antibodies against Ad vectors.

Main Methods:

  • Literature review of adenoviral vector applications.
  • Analysis of strategies for enhancing Ad vector immunogenicity.
  • Discussion of Ad vector-based vaccine and cancer therapy approaches.

Main Results:

  • Adenoviral vectors are effective in eliciting antibody and T cell responses for vaccines.
  • Genetically modified adenoviral vectors can induce cancer cell apoptosis for therapy.
  • Strategies exist to mitigate the impact of pre-existing neutralizing antibodies.

Conclusions:

  • Adenoviral vectors hold significant promise for combating emerging infectious diseases and cancers.
  • Further research into overcoming immune limitations will enhance their therapeutic and prophylactic potential.
  • Ad vector technology is a rapidly advancing field with broad applications in medicine.
Keywords:
adenoviruscancer therapyclinical trialinfectious diseasevaccine

More Related Videos

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches13:36

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

10.8K
Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors14:55

Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors

Published on: December 3, 2013

7.6K

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.3K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.3K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.2K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

3.0K
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
4