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Is Serum Uric Acid Level Correlated with Erectile Dysfunction in Coronary Artery Disease Patients?

Alborz Salavati1, Abdolrasoul Mehrsai1, Farzad Allameh1

  • 1Department of Urology, Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Acta Medica Iranica
|April 25, 2016
PubMed

Insights

Erectile dysfunction (ED) and coronary artery disease (CAD) share risk factors. Elevated uric acid and lipoprotein-a levels are linked to ED in men with CAD, suggesting potential for early detection and management.

Area of Science:

  • Cardiology
  • Urology
  • Metabolic Syndrome

Background:

  • Coronary artery disease (CAD) and vascular insufficiency are linked to modern lifestyle factors.
  • Vasogenic erectile dysfunction (ED) is a common sexual dysfunction that may be preventable by managing shared risk factors with ischemic heart disease.

Purpose of the Study:

  • To investigate the relationship between ED and CAD.
  • To identify potential biomarkers for ED in patients with CAD.

Main Methods:

  • Seventy-five men undergoing coronary angiography completed the IIEF5 questionnaire.
  • Serum levels of lipoprotein-a, uric acid, lipid profile, testosterone, Sex Hormone Binding Globulin (SHBG), and dehydroepiandrosterone sulfate (DHEAS) were measured.
  • Results were compared between ED patients with and without CAD, and CAD patients with normal sexual function.

Main Results:

  • ED prevalence was 30% in CAD patients and 14% in men with normal coronary arteries (P=0.04).
  • ED patients with CAD had significantly higher serum uric acid levels (6.5 ±0.78 mg/dl) compared to ED patients with normal coronary arteries (5.6 ±0.68 mg/dl) (P=0.034).
  • Men with both ED and CAD exhibited higher lipoprotein-a levels than CAD patients with normal sexual function.

Conclusions:

  • Higher serum uric acid and lipoprotein-a levels are correlated with the presence of ED in patients with CAD.
  • These findings suggest that uric acid and lipoprotein-a may serve as indicators for ED in CAD patients.
  • Early identification and management of risk factors for ED and CAD are crucial.

Keywords:
Cronary artery diseaseErectile dysfunctionUric acid

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