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The Oral HIV/AIDS Research Alliance Program: lessons learned and future directions.

C H Shiboski1, J Y Webster-Cyriaque2, M Ghannoum3

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Summary

The Oral HIV/AIDS Research Alliance (OHARA) advanced HIV/AIDS research by standardizing oral disease diagnostics and completing nine studies. This alliance improved understanding of oral complications in patients on antiretroviral therapy (ART).

Keywords:
HIV/AIDSNetwork researchOral lesions

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Area of Science:

  • Oral health research
  • HIV/AIDS clinical research
  • Infectious diseases

Background:

  • The Oral HIV/AIDS Research Alliance (OHARA) was established in 2006 within the ACTG infrastructure.
  • OHARA aimed to investigate oral complications associated with HIV/AIDS.
  • Research focused on the effects of antiretroviral therapy (ART) on opportunistic infections and pathogen resistance.

Purpose of the Study:

  • To provide an overview of OHARA's evolving research agenda.
  • To describe OHARA's key accomplishments and research findings.
  • To outline spin-off projects, lessons learned, and future directions.

Main Methods:

  • Developing and updating diagnostic criteria for oral disease endpoints.
  • Creating standardized training modules for oral disease assessment and specimen collection.
  • Implementing and completing nine research protocols, including domestic and international sites.

Main Results:

  • OHARA successfully developed standardized diagnostic criteria and training modules.
  • Six out of nine implemented protocols were completed, yielding significant findings.
  • Validated laboratory assays were developed for oral HIV/AIDS research.

Conclusions:

  • OHARA has met its goals, significantly contributing to the field of oral HIV/AIDS research.
  • Standardized methods and completed protocols have enhanced the understanding of oral complications in HIV/AIDS.
  • OHARA's work provides a foundation for future research and improved patient care.