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Updated: Mar 22, 2026
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Macular disease detection with a swept-source optical coherence tomography-based biometry device in
Nino Hirnschall1, Christoph Leisser1, Stephan Radda1
1From the Vienna Institute for Research in Ocular Surgery, A Karl Landsteiner Institute (Hirnschall, Leisser, Radda, Mädel, Findl), Hanusch Hospital, Vienna, Austria, and Moorfields Eye Hospital NHS Foundation Trust (Findl), London, United Kingdom.
Purpose:
To assess the sensitivity and specificity for detecting macular disease with a new optical biometry device with swept-source optical coherence tomography (SS-OCT) used before cataract surgery.
Setting:
Hanusch Hospital, Vienna, Austria.
Design:
Consecutive case series.
Methods:
This study included patients with or without macular disease. All patients were scanned using the new biometry device (IOLMaster 700), which allows a 1.0 mm central retinal scan using SS-OCT technology. Also, all eyes were assessed using a dedicated retinal OCT device (RTVue) on the same day. Two experienced examiners and 1 ophthalmology resident graded all scans individually. Sensitivity and specificity for detecting macular disease were assessed, as were the receiver operating characteristic curves.
Results:
Of the 125 eyes included, 5 were excluded from the analysis, 65 had a macular disease, and 55 were healthy. The sensitivity of the biometry device was moderate (between 42% and 68%), and the specificity was high (89% to 98%). Intraobserver reproducibility for assessing the biometry device was 88.3%.
Conclusions:
The biometry device with SS-OCT provided useful information concerning the macula, especially for intraretinal fluid and macular holes. However, it cannot replace a macular OCT device.
Financial Disclosure:
None of the authors has a financial or proprietary interest in any material or method mentioned.
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