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Monoclonal immunoglobulin gene rearrangement in peripheral lymphocytes of a patient with multiple myeloma
A P Palumbo1, A Pileri, S Battaglio
1Department of Medicine and Experimental Oncology, University of Torino, Italy.
Tumori
|February 28, 1989
Abstract:
We analyzed the immunoglobulin (Ig) heavy chain gene rearrangement in the peripheral blood lymphocytes of a patient with multiple myeloma (MM). Although the morphological and immunological examination did not reveal the presence of circulating plasma cells, a monoclonal Ig gene rearrangement was detected. This observation indicates that a monoclonal expansion of circulating B cells was present in the peripheral lymphocytes of this patient.