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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Related Experiment Video

Updated: May 30, 2025

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Cutaneous involvement in multiple myeloma. A rare entity.

L Rapparini1,2, A Pileri1,2, S Robuffo1,2

  • 1Dermatology Unit IRCCS Azienda Ospedaliero-Universitaria di Bologna Bologna Italy.

Clinical Case Reports
|January 27, 2025
PubMed
Summary

Cutaneous involvement in multiple myeloma, a rare condition, often appears late in the disease as nodules. This manifestation indicates an aggressive disease course and a poor prognosis for patients.

Keywords:
cutaneousmetastasismultiple myelomasecondarism

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Area of Science:

  • Hematology
  • Oncology
  • Dermatology

Background:

  • Multiple myeloma is a plasma cell malignancy.
  • Cutaneous involvement is an uncommon manifestation of multiple myeloma.

Purpose of the Study:

  • To describe the characteristics of cutaneous involvement in multiple myeloma.
  • To highlight the prognostic implications of skin lesions in multiple myeloma patients.

Main Methods:

  • Review of clinical data and histopathological findings of patients with multiple myeloma and skin lesions.
  • Analysis of disease course and survival outcomes.

Main Results:

  • Cutaneous lesions in multiple myeloma are rare and can present as nodules.
  • These lesions may mimic other lymphoid neoplasms.
  • Skin involvement typically occurs late in the disease progression.

Conclusions:

  • Cutaneous involvement in multiple myeloma is a sign of advanced disease.
  • It is associated with a poor prognosis and aggressive clinical course.