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Updated: Mar 22, 2026
Quantifying the Binding Interactions Between CuII and Peptide Residues in the Presence and Absence of Chromophores
Published on: April 5, 2022
Synthesis, characterization of new copper (ii) Schiff base and 1,10 phenanthroline complexes and study of their
Pulimamidi Rabindra Reddy1, Suryam Rajeshwar1, Battu Satyanarayana1
1Department of Chemistry, Osmania University, Hyderabad, 500 007, India.
Abstract:
Three mononuclear Cu(II) complexes [Cu(naph-phe)phen] (1), [Cu(naph-tyr)(phen)] (2) and [Cu(naph-trp)(phen)] (3) were synthesized, characterized and their biological properties were studied. Complexes 1, 2, 3 exhibit square pyramidal geometry where Schiff base acts as a binegative tridentate ONO donor ligand and phen acts as NN donor ligand. CT-DNA binding studies revealed that the complexes bind through intercalative mode and show good binding propensity. The hydrolytic DNA cleavage activity of these complexes has been studied using gel electrophoresis. The DNA binding and cleavage affinities decrease in the order of 3>2>1. The in-vitro antimicrobial activities of the complexes were also studied.
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