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A de novo self-assembling peptide hydrogel biosensor with covalently immobilised DNA-recognising motifs
Patrick J S King1, Alberto Saiani2, Elena V Bichenkova1
1Manchester School of Pharmacy, the University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK. Elena.V.Bichenkova@manchester.ac.uk.
Chemical Communications (Cambridge, England)
|April 28, 2016
Abstract:
We report here the first experimental evidence of a self-assembling three-dimensional (3D) peptide hydrogel, with recognition motifs immobilized on the surface of fibres capable of sequence-specific oligonucleotide detection. These systems have the potential to be further developed into diagnostic and prognostic tools in human pathophysiology.
