[Preparation and in vitro study of suppositories containing No-Spa. II. Determination of release of the active...

The authors have made proposal of pharmaceutical technology of a well storable, excellent drug release No-Spa./suppository besides No-Spa./tablets and injection have been in circulation in this country. Without Estaram 299 of small hydroxyl value or combined with 10% ESTASAN oil it suits to therapeutical expectations in every respect. Physical parameters of suppositories and chemical stability of drotaverinium chloride have been excellent on the basis of one year storing. On the ground of in vitro investigations the suppository has been proposed to be introduced to human therapy as antispasmodic preparation.