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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
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[Neonatal herpes simplex infection].

Veronique E J van Ham-Borawitz1, Edo D Stam, Kathleen M Welborn

  • 1Langeland Ziekenhuis, afd. Kindergeneeskunde, Zoetermeer.

Nederlands Tijdschrift Voor Geneeskunde
|April 29, 2016
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Summary
This summary is machine-generated.

Herpes simplex virus (HSV) can cause severe neonatal encephalitis. Early detection of isolated skin lesions in newborns is crucial to prevent central nervous system spread and reduce mortality.

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Area of Science:

  • Neonatology
  • Virology
  • Dermatology

Background:

  • Neonatal encephalitis due to herpes simplex virus (HSV) is a well-known condition with severe outcomes.
  • Isolated skin-eye-mouth disease caused by HSV is less commonly recognized by healthcare professionals.

Observation:

  • This article details two neonates presenting with isolated skin lesions attributed to HSV infection.
  • Approximately 40-45% of neonates infected with HSV exhibit the isolated skin-eye-mouth presentation.

Findings:

  • Prompt antiviral treatment can significantly reduce the risk of central nervous system involvement from 50-60% to 5-10%.
  • Characteristic HSV skin lesions may appear late or be obscured by secondary bacterial infections.

Implications:

  • Immediate HSV testing and treatment are essential for neonates with atypical skin lesions appearing 7-12 days post-birth.
  • Timely intervention is critical to mitigate disease progression and improve neonatal outcomes.