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The cardiovascular phenotype: impact on choice of glucose- lowering therapy

Sanjay Kalra1, Yashdeep Gupta2, Kamal Kishor3

  • 1Department of Endocrinology, Bharti Hospital, Karnal, India.

JPMA. the Journal of the Pakistan Medical Association
|April 29, 2016
PubMed

Insights

Choosing glucose-lowering therapy for diabetes requires assessing cardiovascular health. This bidirectional relationship impacts vital signs, heart function, and arterial health, guiding treatment decisions for type 2 diabetes mellitus.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Cardiovascular outcomes are a primary consideration in selecting glucose-lowering therapies.
  • Cardiovascular health assessment is crucial for guiding treatment choices in individuals with diabetes.

Purpose of the Study:

  • To review the bidirectional relationship between glucose-lowering therapy and cardiovascular health.
  • To describe the clinical aspects of this relationship, termed the cardiovascular phenotype.

Main Methods:

  • Literature review focusing on the interplay between diabetes medications and cardiovascular parameters.
  • Analysis of how vital signs, cardiac autonomic function, myocardial health, and coronary status are affected by glucose-lowering treatments.

Main Results:

  • Glucose-lowering therapies significantly impact cardiovascular outcomes.
  • The choice of therapy influences vital signs, cardiac function, and coronary status.
  • Cerebrovascular and peripheral arterial health are also affected by these treatments.

Conclusions:

  • A comprehensive cardiovascular phenotype assessment is essential for selecting appropriate glucose-lowering therapies.
  • Treatment planning for type 2 diabetes mellitus must integrate cardiovascular health considerations.
  • Understanding this relationship optimizes patient care and reduces cardiovascular risk.

Keywords:
Acarbose, Cardiovascular outcome trials, Cardiovascular Phenotype, Diabetes, Dyslipidaemia, Empagliflozin, Metformin, Obesity, Overweight.

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