Related Experiment Video
Updated: Aug 14, 2026

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
Published on: October 14, 2016
Biology and pathogenesis of CNS leukemia
1Department of Clinical Oncology, University of Washington School of Medicine, Seattle.
Abstract:
Despite routine preventive central-nervous-system (CNS) therapy, 5-10% of children with acute lymphoblastic leukemia continue to suffer CNS relapse. In a majority of these patients, bone marrow relapse ensues and is usually fatal. A better understanding of the biology and pathogenesis of CNS leukemia is needed to develop more effective methods of prevention and treatment of this adverse complication of acute leukemia. Concepts of the origin and proliferation of leukemic cells in the CNS are reviewed, as well postulated mechanisms of their ingress into and egress out of the CNS.
More Related Videos
09:01Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
06:33Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
Published on: November 10, 2023
Related Concept Videos
Differentiation of Common Myeloid Progenitor Cells
Bacterial Meningitis II: Pathophysiology
Encephalitis l: Introduction
Encephalitis ll: Pathophysiology