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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

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Patient-Centered Communication for Discussing Oncotype DX Testing.

Megan C Roberts^1,2, Amy Bryson³, Morris Weinberger^1,4

¹a Department of Health Policy and Management , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.

Cancer Investigation

|April 29, 2016

Summary

Communicating Oncotype DX (ODX) results for breast cancer care presents challenges. A patient-centered approach can improve how oncologists discuss ODX test results and manage uncertainty with patients.

Keywords:

Breast cancer Communication Patient-centered communication Qualitative methods Tumor gene profiling

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Area of Science:

Oncology
Genomics
Health Communication

Background:

Oncotype DX (ODX) testing, a tumor gene expression profile, is increasingly used in breast cancer management.
Effective communication of ODX results is crucial for patient understanding and treatment decisions.
Challenges exist in translating complex genomic information into patient-centered discussions.

Purpose of the Study:

To identify patient-centered communication strategies and gaps in discussing Oncotype DX (ODX) results.
To analyze how oncologists communicate ODX results within a patient-centered framework.
To explore provider perspectives on communicating genomic test results in breast cancer care.

Main Methods:

Qualitative interviews were conducted with oncologists regarding their communication practices for ODX results.
A patient-centered communication framework was applied to analyze the interview data.
Template analysis was performed using Atlas.ti software to identify themes.

Main Results:

Oncologists discussed four key patient-centered communication domains: information exchange, uncertainty assessment, decision-making, and cross-cutting themes.
Providers reported limitations in discussing the emotional aspects of managing uncertainty.
Gaps were identified in assessing patient decision-making preferences and evaluating treatment decisions.

Conclusions:

A patient-centered communication framework offers a valuable model for discussing tumor gene expression tests like ODX.
Addressing communication gaps, particularly around emotional support and shared decision-making, can enhance patient care.
Further research should focus on optimizing communication strategies for genomic testing in oncology.