Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Filtration and Urine Formation

Filtration and Urine Formation

The function of the kidneys is to filter, reabsorb, secrete, and excrete. Every day the kidneys filter nearly 180 liters of blood, initially removing water and solutes but ultimately returning nearly all filtrates into circulation with the help of osmoregulatory hormones. This process removes wastes and toxins but is also crucial to maintain water and electrolyte levels. Most of these functions are performed by the tiny but numerous nephrons contained within the kidneys.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Simple Health-Related Social Needs Referral Workflow in a Pediatric Emergency Department.

Academic pediatrics·2026

Same author

Adjustable-Error-Based Adaptive Neural Network Tracking Control for Uncertain Nonlinear Systems.

IEEE transactions on cybernetics·2026

Same author

Therapeutic optimization of LIPA targeting to induce endoplasmic reticulum stress and cell death in ovarian cancer.

Oncogene·2026

Same author

Cooperative control for FWID-EVs with active suspension under extreme conditions by using off-policy safe reinforcement learning.

ISA transactions·2026

Same author

Microbial Product Cocktails for Personalized Cancer Immunotherapy.

Nature communications·2025

Same author

Assessing deep learning models for multi-class upper endoscopic disease segmentation: A comprehensive comparative study.

World journal of gastroenterology·2025

Search research articles

Related Experiment Video

Updated: Mar 22, 2026

A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.

A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.

Published on: July 9, 2012

A Microfiltration Device for Urogenital Schistosomiasis Diagnostics.

Yuan Xiao^1,2, Yi Lu^1,2, Michael Hsieh³

¹Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, United States of America.

|April 29, 2016

Summary

This study developed a microfiltration device to rapidly detect schistosome eggs in urine, aiding urogenital schistosomiasis diagnostics. The innovative microfluidic trap efficiently isolates and characterizes parasite eggs for improved disease detection.

More Related Videos

Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum

Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum

Published on: May 22, 2018

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation

Published on: June 5, 2012

Related Experiment Videos

Last Updated: Mar 22, 2026

A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.

A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.

Published on: July 9, 2012

Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum

Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum

Published on: May 22, 2018

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation

Published on: June 5, 2012

Area of Science:

Parasitology
Biomedical Engineering
Microfluidics

Background:

Schistosomiasis is a major global parasitic disease affecting over 200 million people.
Urogenital schistosomiasis diagnosis relies on detecting Schistosoma haematobium eggs in urine.
Current diagnostic methods can be time-consuming and lack sensitivity for low parasite loads.

Purpose of the Study:

To design and develop a microfluidic device for efficient isolation and characterization of schistosome eggs from urine.
To enable rapid and sensitive diagnostics for urogenital schistosomiasis.
To facilitate downstream analysis and in-situ characterization of trapped parasite eggs.

Main Methods:

Development of a microfiltration device featuring a linear array of microfluidic traps.
Utilizing flow resistance for autonomous sequential loading and immobilization of individual eggs.
Employing computational fluid dynamics modeling and experimental characterization for optimization.
On-chip phenotyping using confocal laser fluorescence microscopy.

Main Results:

The microfluidic device achieved 100% trapping efficiency at 300 μl/min and 83% at 3000 μl/min.
Filtration and egg isolation completed within 10 minutes.
Successful in-situ characterization of trapped Schistosoma haematobium eggs using fluorescence microscopy.
Demonstrated potential for both recovery and preservation of eggs for further analysis.

Conclusions:

The developed microfiltration device offers a novel and efficient microfluidic approach for trapping and counting urinal Schistosoma haematobium eggs.
This technology provides a valuable tool for rapid diagnostics and clinical investigation of urogenital schistosomiasis.
The device enables on-chip fluorescence characterization, enhancing diagnostic capabilities.