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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.5K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.4K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.4K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

1.0K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.0K
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

910
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

722
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
722
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

895
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
895

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Related Experiment Video

Updated: Mar 22, 2026

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
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[Hormonal changes in inflammatory bowel disease].

Jana Kollerová, Tomáš Koller, Tibor Hlavatý

    Vnitrni Lekarstvi
    |April 30, 2016
    PubMed
    Summary

    Inflammatory bowel disease (IBD) is linked to endocrine system disorders, affecting hormones, fertility, and bone health. These conditions mutually influence each other, requiring further research for better patient management.

    Area of Science:

    • Gastroenterology and Endocrinology

    Background:

    • Inflammatory bowel disease (IBD) encompasses Crohn's disease and ulcerative colitis.
    • IBD is associated with extraintestinal manifestations stemming from autoimmune processes, inflammation, nutritional deficiencies, and treatments.
    • Endocrine system dysfunction is a recognized extraintestinal manifestation of IBD.

    Purpose of the Study:

    • To analyze the intricate relationship between IBD and various endocrine functions.
    • To investigate the impact of IBD on gonadal hormone production, fertility, adrenal function, thyroid health, growth hormone, and bone mineral density.
    • To highlight the bidirectional influence between IBD and endocrine disorders.

    Main Methods:

    • Review and analysis of existing literature on the correlation between IBD and endocrine system changes.

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  • Examination of functional and morphological alterations in endocrine tissues associated with Crohn's disease and ulcerative colitis.
  • Assessment of the impact of endocrine disorders on the progression of IBD.

    • Main Results:

    • IBD is associated with alterations in gonadal hormone production and fertility.
    • Changes in adrenal function and thyroid morphology/function are observed in IBD patients.
    • Growth hormone production and bone mineral density are negatively affected in individuals with IBD, particularly children.

    Conclusions:

    • The interaction between IBD and the endocrine system is bidirectional and significant.
    • Endocrine disorders can exacerbate IBD, while IBD can lead to endocrine dysfunction.
    • Further research is crucial to fully elucidate these complex interactions and improve therapeutic strategies for IBD patients.