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Fluindione can cause acute kidney injury, known as drug-induced interstitial nephritis (IN). This case highlights a rare instance of subacute IN developing two years after starting fluindione treatment.

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Area of Science:

  • Nephrology
  • Pharmacology
  • Internal Medicine

Background:

  • Fluindione is a known cause of acute drug-induced interstitial nephritis (IN).
  • Most reported cases of fluindione-induced IN occur early in the course of treatment.

Purpose of the Study:

  • To report a unique case of subacute fluindione-induced interstitial nephritis.
  • To emphasize the possibility of delayed IN onset.

Main Methods:

  • Case report of a patient diagnosed with subacute interstitial nephritis.
  • Analysis of clinical presentation, diagnosis, and treatment response.

Main Results:

  • A severe case of subacute fluindione-induced IN was diagnosed 2 years after initiating treatment.
  • Significant improvement in renal function was observed following drug withdrawal and corticosteroid administration.

Conclusions:

  • Fluindione can induce interstitial nephritis with a delayed, subacute presentation.
  • Early recognition and discontinuation of the causative agent, alongside steroid therapy, are crucial for renal recovery.