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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Pigmentation01:19

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Related Experiment Video

Updated: Mar 22, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Primary small bowel melanomas: fact or myth?

Andreas V Hadjinicolaou1, Christopher Hadjittofi1, Panagiotis G Athanasopoulos1

  • 11 Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, UK ; 2 Department of Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London, UK ; 3 Department of HPB & Liver Transplant Surgery, Royal Free Hospital, London, UK ; 4 Department of Gastroenterology, Frimley Park NHS Foundation Trust, Portsmouth Road, Frimley, Surrey, UK ; 5 Department of Gastroenterology, Royal Surrey Hospital, Guildford, UK.

Annals of Translational Medicine
|April 30, 2016
PubMed
Summary

This report details a rare case of primary small bowel melanoma (SBM) in a 60-year-old man. Capsule endoscopy proved crucial in diagnosing this elusive gastrointestinal cancer, highlighting its diagnostic capabilities.

Keywords:
Bowelcapsuleendoscopyintestinemelanoma

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Area of Science:

  • Gastroenterology and Oncology
  • Surgical Pathology

Background:

  • Small bowel melanoma (SBM) is an exceedingly rare gastrointestinal malignancy.
  • The origin of SBM, whether primary or metastatic, remains a subject of debate.
  • Late diagnosis is common due to the elusive nature of SBM.

Observation:

  • A 60-year-old male presented with melena and microcytic anemia.
  • Initial investigations including ultrasonography, EGD, colonoscopy, and CT scan were unremarkable.
  • Capsule endoscopy revealed a jejunal mass, later confirmed as melanoma via laparotomy and histology.

Findings:

  • The resected jejunal mass was histologically diagnosed as melanoma.
  • Postoperative examination revealed no evidence of primary cutaneous melanoma.
  • This case supports the existence of primary small bowel melanoma.

Implications:

  • Capsule endoscopy is a valuable tool for diagnosing rare gastrointestinal tumors.
  • Further research into the pathophysiology of SBM is needed.
  • Early diagnosis and treatment are crucial for improving outcomes in SBM.