Related Experiment Video
Updated: Mar 22, 2026

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
Published on: September 27, 2024
Leg Rejuvenation: A Combination Approach: A Review and Our Experience
Margaret Weiss1, Anne M Mahoney, Michael Gold
1*Maryland Laser, Skin and Vein Institute, Hunt Valley, Maryland; †Gold Skin Care Center, Nashville, Tennessee; ‡Division of Dermatology, Section of Procedural Dermatology, Cooper University Health Care, Marlton, New Jersey.
Background:
Patients increasingly seek to enhance the appearance of their legs. Elimination of unwanted leg veins, reduction of epidermal photo-aging changes such as solar lentigines and keratoses, tightening of skin laxity and reduction of adipose tissue are among the most commonly requested goals. Many patients require a combination approach to address their concerns. It is important for dermatologists to be aware of the multitude of procedures that can be performed, often in combination, to rejuvenate the leg.
Objective:
The purpose of this review article was to discuss procedures for improving the appearance of the leg and to share the authors experience, especially in the combination approach to leg rejuvenation.
Methods:
A literature search was performed to investigate cosmetic procedures being performed on the leg, with an emphasis on controlled or randomized studies. In addition, the authors contributed their personal experience.
Results:
Our discussion of the literature review highlights the treatments for leg veins, unwanted fat, cellulite, and photodamage of the legs that are most supported in peer-reviewed publications.
Conclusion:
A synergistic, combination approach to leg rejuvenation works best. This includes the use of injectable agents, energy-based devices, and more invasive surgical procedures.
Related Concept Videos
Tissue Renewal without Stem Cells
However, failure of such a system...
Whole Body Regeneration
Renewal of Skin Epidermal Stem Cells
The Effect of Aging on Tissues
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

