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Updated: Mar 22, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

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Association Between Chlamydia pneumoniae and Migraine: A Study from a Tertiary Center in India

Jaydip Ray Chaudhuri, K Rukmini Mridula, Anthati S Keerthi

    Journal of Oral & Facial Pain and Headache
    |April 30, 2016
    PubMed
    Abstract

    Insights

    The presence of Chlamydia pneumoniae (C pneumoniae) immunoglobulin G (IgG) antibody is linked to migraines in Indian patients. This finding suggests a potential role for C pneumoniae infection in migraine development.

    Area of Science:

    • Infectious Diseases
    • Neurology
    • Immunology

    Background:

    • Migraine is a prevalent neurological disorder with complex pathophysiology.
    • Infectious agents have been implicated in various chronic conditions, including neurological disorders.

    Purpose of the Study:

    • To investigate the association between Chlamydia pneumoniae (C pneumoniae) immunoglobulin G (IgG) antibody and migraine in Indian patients.

    Main Methods:

    • A case-control study involving 300 migraine patients and 150 controls in Hyderabad, India.
    • Assessed for C pneumoniae IgG antibody, C-reactive protein (CRP), and depression (Hamilton Depression Rating Scale).

    Main Results:

    • C pneumoniae IgG antibody positivity was significantly higher in migraine patients (50.3%) compared to controls.
    • Migraine patients also showed higher rates of CRP, depression, and sleep disturbances.
    • C pneumoniae IgG antibody, CRP, depression, and sleep disturbances were independently associated with migraine.

    Conclusions:

    • The presence of C pneumoniae IgG antibody is independently associated with migraine in Indian patients.
    • This suggests a potential role for C pneumoniae infection in the pathogenesis of migraine.

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