Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

7.3K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
7.3K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

17.6K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
17.6K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

86.0K
Overview
86.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance.

Nature cell biology·2026
Same author

Ill Fate of Rectal Mucinous Adenocarcinoma: A Defect in Immunosurveillance or a Mucin Coating Effect?-The IMMUNOREACT 20 Study.

Cancers·2026
Same author

Assessment of Vedolizumab and UC-MSC interaction and therapeutic potential in acute graft-versus-host-disease.

Frontiers in cell and developmental biology·2026
Same author

Manufacturing 3D aortic root models for in vitro assessment of calcific aortic valve stenosis.

Annals of biomedical engineering·2026
Same author

Gut microbiota-associated predictors as biomarkers of neoadjuvant treatment response in rectal cancer-a systematic review.

British journal of cancer·2026
Same author

Targeting peptidyl-arginine deiminase 4 suppresses SARS-CoV-2 replication and modulates the inflammatory response.

iScience·2026

Related Experiment Video

Updated: Mar 21, 2026

Gene Editing of Primary Rhesus Macaque B Cells
09:53

Gene Editing of Primary Rhesus Macaque B Cells

Published on: February 10, 2023

3.1K

Reverse immunoediting: When immunity is edited by antigen.

Anna Merlo1, Silvia Dalla Santa2, Riccardo Dolcetti3

  • 1Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128 Padua, Italy.

Immunology Letters
|May 2, 2016
PubMed
Summary

Cancer immunoediting involves a two-way street: tumors shape immune responses, and antigens can shape immunity. Understanding this "reverse immunoediting" is key for effective cancer immunotherapy.

Keywords:
AntigenCancerImmunodominanceImmunoeditingImmunotherapyVirus

More Related Videos

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
08:12

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes

Published on: November 1, 2011

20.5K
CRISPR/Cas9 Editing of the C. elegans rbm-3.2 Gene using the dpy-10 Co-CRISPR Screening Marker and Assembled Ribonucleoprotein Complexes.
07:46

CRISPR/Cas9 Editing of the C. elegans rbm-3.2 Gene using the dpy-10 Co-CRISPR Screening Marker and Assembled Ribonucleoprotein Complexes.

Published on: December 11, 2020

6.6K

Related Experiment Videos

Last Updated: Mar 21, 2026

Gene Editing of Primary Rhesus Macaque B Cells
09:53

Gene Editing of Primary Rhesus Macaque B Cells

Published on: February 10, 2023

3.1K
Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
08:12

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes

Published on: November 1, 2011

20.5K
CRISPR/Cas9 Editing of the C. elegans rbm-3.2 Gene using the dpy-10 Co-CRISPR Screening Marker and Assembled Ribonucleoprotein Complexes.
07:46

CRISPR/Cas9 Editing of the C. elegans rbm-3.2 Gene using the dpy-10 Co-CRISPR Screening Marker and Assembled Ribonucleoprotein Complexes.

Published on: December 11, 2020

6.6K

Area of Science:

  • Immunology
  • Oncology
  • Cancer Research

Background:

  • Cancer immunoediting describes how the immune system shapes tumors.
  • During the "Escape" phase, tumors can also influence the immune response.
  • This suggests a reciprocal interaction between the tumor and the immune system.

Purpose of the Study:

  • To propose and explore the concept of "reverse immunoediting" where antigens shape the immune response.
  • To highlight the bidirectional nature of tumor-immune system interactions.
  • To emphasize the importance of antigen characteristics in immunotherapy design.

Main Methods:

  • Conceptual framework development.
  • Literature review and synthesis.
  • Hypothesis formulation based on existing immunological principles.

Main Results:

  • Immune selective pressure sculpts tumors, but antigens also shape immune responses.
  • A reciprocal modeling process, termed "reverse immunoediting," likely occurs continuously.
  • Antigen features (type, load, presentation) are critical for T cell responses.

Conclusions:

  • The "reverse immunoediting" hypothesis offers a new perspective on tumor-immune interplay.
  • Considering antigen characteristics is crucial for designing effective immunotherapies.
  • This framework can improve T cell-based cancer treatment strategies.