Patient Satisfaction With Collagenase.

Area of Science:

• Hand surgery
• Pharmacological treatments
• Patient-reported outcomes

Background:

• Dupuytren disease is a progressive condition affecting hand function.
• Collagenase clostridium histolyticum (CCH) is an enzymatic injection treatment for Dupuytren disease.
• Assessing patient satisfaction is vital for treatment evaluation.

Purpose of the Study:

• To evaluate patient satisfaction following collagenase clostridium histolyticum (CCH) injections for Dupuytren disease.
• To identify factors influencing patient satisfaction with CCH treatment.
• To compare patient preference for CCH versus surgical intervention.

Main Methods:

• A cross-sectional study reviewed 213 patients treated with CCH for Dupuytren disease.
• Data collected between 37 and 1421 days post-injection.
• Patient satisfaction assessed using Likert scales and functional outcome measures (QuickDASH, Southampton Dupuytren Scoring Scheme).

Main Results:

• 73% of patients reported high satisfaction (very satisfied or satisfied).
• Satisfaction and willingness for retreatment decreased over time and correlated negatively with disease recurrence.
• 71% of patients with prior surgery preferred CCH over surgery; satisfaction linked to functional outcomes.

Conclusions:

• Patient satisfaction with CCH for Dupuytren disease is generally high, particularly initially.
• Satisfaction declines over time due to disease recurrence, necessitating explicit discussion during patient consent.
• Forewarning patients about potential complications and recurrence can help manage expectations and maintain satisfaction.