Related Experiment Video
Updated: Mar 21, 2026

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
Published on: May 24, 2017
RNA systems biology: uniting functional discoveries and structural tools to understand global roles of RNAs
Eric J Strobel1, Kyle E Watters1, David Loughrey1
1School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, United States.
Abstract:
RNAs assume sophisticated structures that are active in myriad cellular processes. In this review, we highlight newly identified ribozymes, riboswitches, and small RNAs, some of which control the function of cellular metabolic and gene expression networks. We then examine recent developments in genome-wide RNA structure probing technologies that are yielding new insights into the structural landscape of the transcriptome. Finally, we discuss how these RNA 'structomic' methods can address emerging questions in RNA systems biology, from the mechanisms behind long non-coding RNAs to new bases for human diseases.
Related Concept Videos
Types of RNA
RNA Performs Diverse...
Types of RNA
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA
Types of RNA
Ribosomal RNA Synthesis
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Riboswitches
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...

