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Fatigue and Comorbidities in Multiple Sclerosis.

Kirsten M Fiest1, John D Fisk1, Scott B Patten1

  • 1Department of Internal Medicine, College of Medicine, Faculty of Health Sciences (KMF, RAM), and Department of Community Health Sciences, College of Medicine (RAM), University of Manitoba, Winnipeg, MB, Canada; Departments of Psychiatry, Medicine, Psychology, and Neuroscience, Dalhousie University, Halifax, NS, Canada (JDF); Departments of Psychiatry and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada (SBP); Division of Neurology, Faculty of Medicine (HT), and Department of Experimental Medicine (KAM), University of British Columbia, Vancouver, BC, Canada; Departments of Epidemiology and Biostatistics, Occupational Health, and Medicine, McGill University, Montreal, QC, Canada (CW); Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada (SW); and Department of Psychology, St. Francis Xavier University, Antigonish, NS, Canada (LIB).

International Journal of MS Care
|May 3, 2016
PubMed
Summary
This summary is machine-generated.

Comorbidities like depression, irritable bowel syndrome, migraine, and anxiety are linked to persistent fatigue in multiple sclerosis (MS). Depression also increases the risk of worsening fatigue over time.

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Area of Science:

  • Neurology
  • Clinical Research
  • Patient Outcomes

Background:

  • Fatigue is a prevalent symptom in multiple sclerosis (MS).
  • The relationship between comorbidities and fatigue in MS is not well understood.
  • Understanding this link is crucial for managing MS patient well-being.

Purpose of the Study:

  • To investigate the association between comorbidities and fatigue in individuals with MS.
  • To determine if specific comorbidities predict the presence or worsening of fatigue over time.
  • To explore the impact of depression on fatigue persistence and progression in MS.

Main Methods:

  • A cohort of 949 individuals with definite MS was followed for 2 years across four Canadian centers.
  • Fatigue was assessed using the Fatigue Impact Scale for Daily Use.
  • Comorbidities were evaluated using a validated questionnaire, with logistic regression analyzing associations with fatigue.
  • Participants were categorized into 'no fatigue' and 'any fatigue' groups.

Main Results:

  • The incidence of fatigue during the study was 38.8%.
  • Older age, longer disease duration, and greater disability were associated with higher fatigue prevalence.
  • Depression, irritable bowel syndrome, migraine, and anxiety were independently linked to persistent fatigue.
  • Depression showed an individual-level effect on worsening fatigue over the 2-year period.

Conclusions:

  • Comorbidities significantly associate with fatigue in MS patients.
  • Depression is a key comorbidity linked to both persistent and worsening fatigue.
  • Further research is needed to elucidate the mechanisms underlying the influence of comorbidities on MS-related fatigue.