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Related Experiment Video

Updated: May 13, 2025

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Resilience Indirectly Affects Functional Capabilities Through Physical Activity Engagement in Individuals With

Elizabeth S Gromisch1,2,3,4, Aaron P Turner5,6,7, Lindsay O Neto1,2

  • 1Mandell Center for Multiple Sclerosis, Mount Sinai Rehabilitation Hospital, Trinity Health Of New England, Hartford, CT.

International Journal of MS Care
|April 15, 2025
PubMed
Summary

Resilience in multiple sclerosis (MS) patients indirectly improves physical functioning by encouraging physical activity. This highlights resilience

Keywords:
daily functioninglifestyle behaviorsphysical activityresilience

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Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Psychology

Background:

  • The relationship between resilience and functional outcomes in multiple sclerosis (MS) is under investigation.
  • A proposed mechanism suggests that resilient individuals with MS engage more in healthy lifestyle behaviors, leading to better functioning.
  • This study explores the indirect influence of resilience on functioning in MS through lifestyle behaviors.

Purpose of the Study:

  • To investigate whether resilience influences functional capabilities in individuals with MS.
  • To examine if this influence is mediated by specific lifestyle behaviors.
  • To understand the pathway linking resilience, lifestyle, and physical function in MS.

Main Methods:

  • Sixty-four individuals with MS completed validated questionnaires for resilience (MSRS), lifestyle behaviors, and physical function (PROMIS-PF).
  • Mediation models were employed to analyze the relationship between resilience (independent variable), lifestyle behaviors (mediators), and physical function (dependent variable).
  • Demographic and disease-related factors were included as covariates in the analysis.

Main Results:

  • Physical activity was identified as the sole lifestyle behavior significantly associated with improved physical functioning (ρ = 0.43, P < .001).
  • Resilience demonstrated a significant indirect effect on physical functioning, mediated by physical activity (b = 0.16; 95% CI, 0.04-0.32).
  • The direct effect of resilience on physical functioning was not statistically significant (b = -0.02, P = .860).

Conclusions:

  • Resilience indirectly enhances physical functioning in individuals with MS primarily through increased engagement in physical activity.
  • These findings underscore the critical role of resilience in fostering well-being and functional capacity among those with MS.
  • Interventions promoting resilience may improve physical activity levels and subsequent functioning in the MS population.