[Modification of blood plasma lipoproteins by a lipid peroxidation product--hexanal]

HDL treated with hexanal is shown to lose the ability for the cholesterol absorption. In the case of LDL at low concentration of the modifying agent the rate of their elimination from the blood stream of the rabbit decrease, but their uptake by the rat macrophages do not differ from the uptake of native lipoproteins. At high concentration of hexanal the rate of the elimination of LDL from the blood stream increases considerably and is close to that of acetylated LDL. Thus, the modification of plasma lipoproteins with monoaldehydes occurring in the aorta wall leads to the loss of the functional properties of the lipoprotein particles.