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Age Related Changes in Autonomic Functions.

Rachna Parashar1, Mohammed Amir2, Abhijit Pakhare3

  • 1Assistant Professor, Department of Physiology, AIIMS , Bhopal, (M.P), India .

Journal of Clinical and Diagnostic Research : JCDR
|May 3, 2016
PubMed
Summary
This summary is machine-generated.

Autonomic nervous system functions, including sympathetic and parasympathetic responses, significantly decline with age. Sudomotor functions are also impaired in the elderly, highlighting age-related changes in autonomic regulation.

Keywords:
Adrenergic and sudomotor functionsAgeingAutonomic functionsCardio-vagalDifferent age groups

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Area of Science:

  • Physiology
  • Gerontology
  • Autonomic Neuroscience

Background:

  • Autonomic Nervous System (ANS) imbalance can precipitate or exacerbate organ system pathologies, with variations across different age demographics.
  • Understanding age-related changes in ANS function is crucial for identifying and managing associated health risks.

Purpose of the Study:

  • To investigate the association between different age groups and autonomic function.
  • To evaluate age-related alterations in cardio-vagal, adrenergic, and sudomotor functions.

Main Methods:

  • A cross-sectional study involving 62 healthy volunteers stratified into younger (15-45), middle (45-60), and elder (above 60) age groups.
  • Autonomic functions assessed included cardio-vagal (Deep Breathing Test, Valsalva, 30:15 ratio), adrenergic (Orthostatic Hypotension Test), and sudomotor functions.
  • Statistical analysis employed ANOVA and Chi-square tests, with a significance level of p<0.05.

Main Results:

  • Orthostatic Hypotension Test revealed a significant decline in sympathetic function with increasing age (p<0.001).
  • Cardio-vagal responses, measured by DBT, Valsalva, and 30:15 ratio, showed a statistically significant decrease with advancing age (p<0.001).
  • Sudomotor responses were normal in younger and middle groups but impaired in over half of the elderly participants (p<0.001).

Conclusions:

  • Both sympathetic and parasympathetic nervous system responses demonstrate a significant decline with increasing age.
  • Sudomotor responses are partially interrupted in the elderly population, indicating age-related autonomic dysfunction.