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Neutrophil-Lymphocyte Ratio in Patients with Adenoidectomy
Serhan Derin1, Selvet Erdogan2, Murat Sahan1
1Faculty, Department of Otorhinolaryngology, Mugla Sitki Kocman University, School of Medicine , Mugla/Turkey .
Insights
This study found no significant change in neutrophil-lymphocyte ratio (NLR) after adenoidectomy in children with obstructive sleep apnea (OSA). Adenoidectomy did not appear to alter this inflammatory marker, suggesting NLR is unrelated to upper airway obstruction severity.
Area of Science:
- Pediatric Otolaryngology
- Sleep Medicine
- Pediatric Pulmonology
Background:
- Adenoid hypertrophy (AH) is a common cause of obstructive sleep apnea (OSA) in children, leading to nocturnal hypoxia.
- Childhood OSA is linked to potential long-term cardiovascular issues.
- The neutrophil-lymphocyte ratio (NLR) is an emerging inflammatory marker.
Purpose of the Study:
- To investigate the preoperative and postoperative NLR values in children undergoing adenoidectomy.
- To explore the association between NLR and adenoid hypertrophy (AH) causing OSA in pediatric patients.
Main Methods:
- The study included 76 children who underwent adenoidectomy.
- Complete blood cell counts were analyzed preoperatively and 3 months postoperatively to calculate NLR.
- NLR was determined as the ratio of neutrophils to lymphocytes in peripheral blood.
Main Results:
- The mean NLR showed no statistically significant difference between preoperative (1.0) and 3-month postoperative (1.06) values (p = 0.052).
- Hemoglobin and white blood cell counts remained stable post-surgery.
- Platelet counts showed a statistically significant decrease post-surgery (p<0.005).
Conclusions:
- The neutrophil-lymphocyte ratio (NLR) is not a statistically significant inflammatory factor in children undergoing adenoidectomy for OSA.
- Postoperative NLR values do not appear to be related to the stage of upper airway obstruction.
- Further research is needed to fully understand the role of NLR in pediatric OSA.
Introduction:
Obstructive Sleep Apnea syndrome (OSA) is the most serious consequence of adenoid hypertrophy (AH) and it is one of the most common reasons of nocturnal hypoxia in children. There is some information about the relationship between childhood OSA and atherosclerosis or cardiac diseases. In this study, we evaluated the relationship between, neutrophil-lymphocyte ratio (NLR) and AH which is the most frequent cause leading OSA in children.
Aim:
Thus we aimed to contribute about subject of preoperative and postoperative NLR values in patients undergoing adenoidectomy that there is limited information.
Materials And Methods:
The study group comprised 76 children undergoing adenoidectomy. A preoperative and 3(rd)-month postoperative complete blood cell count was performed to calculate the NLR values in all patients. The NLR values were calculated as the ratio of neutrophils to lymphocytes in peripheral blood. Data analysis was performed using SPSS 15.
Results:
The mean NLR (min - max) was 1.0 (0.16-3.57) preoperatively and 1.06 (0.35-4.95) 3 months postoperatively (p = 0.052> 0.05). Haemoglobin 12.9 ± 0.95 (preop) 12.94 ± 0.91 (postop) (p= 0.522), WBC (min-max) 7.75 (3.90-14.99) 7.8 (4-15.64) (p= 0.297 <0.005), platelet 344.5 ± 98.7 328.4 ± 68.9 (p<0,005).
Conclusion:
There is limited information in the English literature. This study has investigated the association between the NLR and adenoidectomy. The results of the present study demonstrate that the NLR is not a statistically significant inflammatory factor. So, NLR values do not appear related to stage of upper airway obstruction.
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