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Pediatric Reference Intervals for Complete Blood Count Parameters in Healthy Turkish Infants and Children
Ünsal Özgen1, Filiz Orhon2, Gonca Keskindemirci3
1Medical Faculty, Department of Pediatrics, Division of Pediatrics Hematology Oncology, Ondokuz Mayıs University, Samsun, Türkiye.
International Journal of Laboratory Hematology
|March 7, 2026
Summary
This study establishes crucial reference ranges for complete blood count (CBC) parameters in healthy Turkish children. These findings offer a vital resource for accurate pediatric hematological assessments nationwide.
Area of Science:
- Pediatric Hematology
- Clinical Pathology
- Reference Range Establishment
Background:
- Accurate reference ranges for complete blood count (CBC) parameters are essential for diagnosing and monitoring various pediatric health conditions.
- Existing CBC reference ranges may not accurately reflect the diverse pediatric population in Türkiye.
- Establishing region-specific reference intervals is critical for precise clinical interpretation.
Purpose of the Study:
- To determine and provide comprehensive reference ranges for complete blood count (CBC) parameters in healthy children residing in Türkiye.
- To establish age- and sex-stratified reference intervals for key hematological indicators.
- To create a foundational dataset for improved pediatric hematological evaluations in Türkiye.
Main Methods:
- A large cohort of 24,115 healthy children aged 1 month to 18 years were enrolled across 10 centers in Türkiye.
- Complete blood count (CBC) measurements were systematically collected from participants attending Well Child Outpatient Clinics.
- Data were analyzed to determine mean, median, and nonparametric reference intervals (2.5th-97.5th percentile) stratified by age and sex.
Main Results:
- The study presents mean and median values for red blood cell, white blood cell, and platelet parameters across various pediatric age groups.
- Nonparametrically determined CBC reference intervals (RIs) for the 2.5th to 97.5th percentile were provided, stratified by age and sex.
- Detailed hematological data were compiled for a large, diverse population of healthy Turkish children.
Conclusions:
- This research provides the first established reference ranges for hematological parameters specifically for Turkish children under 18 years of age.
- The generated reference intervals offer a more reliable and accurate basis for hematological evaluations in pediatric healthcare across Türkiye.
- These findings will support clinicians in the precise interpretation of CBC results, enhancing diagnostic accuracy and patient care.
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