Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Design Example: Alignment of a Road Line Using GIS01:17

Design Example: Alignment of a Road Line Using GIS

402
The alignment of a road line using Geographic Information Systems (GIS) is a critical process in civil engineering, combining advanced technology with practical decision-making. This methodology begins with the collection of geospatial data, including information on land cover, geomorphology, drainage patterns, slope, and contour details. Such data is typically acquired through satellite imagery and GIS tools, offering a comprehensive understanding of the terrain.Once the data is gathered, it...
402

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[DNA informs on ancient partner choice].

Medecine sciences : M/S·2026
Same author

[TimeVaults provide recordings of past cellular activity].

Medecine sciences : M/S·2026
Same author

[In vivo CAR-Ts, a significant breakthrough].

Medecine sciences : M/S·2026
Same author

[House of cards?]

Medecine sciences : M/S·2026
Same author

[Towards gene therapy for Hutington's disease].

Medecine sciences : M/S·2025
Same author

[DNA reveals the living world].

Medecine sciences : M/S·2025

Related Experiment Video

Updated: Mar 21, 2026

Author Spotlight: Exploring Seaweed's Bioactive Compounds for Sustainable Innovations in Industries
10:18

Author Spotlight: Exploring Seaweed's Bioactive Compounds for Sustainable Innovations in Industries

Published on: November 21, 2023

3.7K

[Is Grail's goal feasible?].

Bertrand Jordan1

  • 1UMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS, Espace éthique méditerranéen, hôpital d'adultes la Timone, 264, rue Saint-Pierre, 13385 Marseille Cedex 05, France - CoReBio PACA, case 901, parc scientifique de Luminy, 13288 Marseille Cedex 09, France.

Medecine Sciences : M/S
|May 4, 2016
PubMed
Summary
This summary is machine-generated.

Grail aims for a new liquid biopsy test for early cancer detection. However, achieving the required specificity to prevent false positives may be impossible, potentially causing more harm than benefit.

More Related Videos

Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections
12:21

Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections

Published on: October 31, 2017

7.9K
Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography
06:53

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

15.2K

Related Experiment Videos

Last Updated: Mar 21, 2026

Author Spotlight: Exploring Seaweed's Bioactive Compounds for Sustainable Innovations in Industries
10:18

Author Spotlight: Exploring Seaweed's Bioactive Compounds for Sustainable Innovations in Industries

Published on: November 21, 2023

3.7K
Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections
12:21

Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections

Published on: October 31, 2017

7.9K
Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography
06:53

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

15.2K

Area of Science:

  • Oncology
  • Genomics
  • Medical Diagnostics

Background:

  • A new "liquid biopsy" test is proposed for asymptomatic cancer detection and general screening.
  • The test aims to detect cancer early using ultra-deep sequencing of plasma DNA.

Purpose of the Study:

  • To evaluate the feasibility of a highly sensitive and specific liquid biopsy test for widespread cancer screening.
  • To assess whether the required specificity can be achieved to avoid harmful false positives.

Main Methods:

  • Analysis of the technical requirements for ultra-deep sequencing of cell-free DNA.
  • Evaluation of specificity challenges in current cancer screening methods.

Main Results:

  • While high sensitivity for cancer detection may be achievable with advanced sequencing techniques.
  • Achieving the extremely high specificity needed to minimize false positives remains a significant challenge.

Conclusions:

  • The proposed liquid biopsy test's high specificity requirement may be unattainable.
  • Insufficiently specific screening tests can lead to harms that outweigh their benefits, as seen with PSA and mammography.