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Primary intracranial neuroendocrine tumor: two case reports
Hailong Liu1, Haoran Wang1, Xueling Qi1
1Department of Neurosurgery, Sanbo Brain Hospital Capital Medical University, No. 50 Xiang Shan Yi-Ke-Song, Haidian District, Beijing, 100093, People's Republic of China.
Background:
Neuroendocrine tumor originates from the diffuse neuroendocrine system. Intracranial originating is lower to 0.74 %.
Case Presentation:
We present two cases of primary intracranial neuroendocrine tumor A 39-year-old woman was admitted with headache, fever, polydipsia and polyuria. Biochemical and endocrinological results showed hyponatremia, hypothyroidism and hypopituitarism. MRI scans demonstrated an obviouslyenhancing lesion in seller and superseller area. Then a gross removal of tumor was achieved during the single nostril transsphenoidal approach surgery. Pathological diagnosis was high-grade small-cell neuroendocrine tumor. A 40-year-old woman presented with multiple symptoms and neurological deficit. Neuroimaging results demonstrated a huge obviously-enhancing tumor in anterior cranial fossa. Biochemical and hormone findings revealed hypokalemia, high glucose and hypercortisolemia. The intracranial surgery achieved a gross removal through a right frontal craniotomy. Pathological diagnosis was low-grade small-cell neuroendocrine tumor with immuno-negativity for ACTH.
Conclusion:
The mechanism, diagnosis, and treatment of neuroendocrine tumor are still challenging.
