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Gold and diazo reagents: a fruitful tool for developing molecular complexity
Manuel R Fructos1, M Mar Díaz-Requejo, Pedro J Pérez
1Laboratorio de Catálisis Homogénea, Unidad Asociada al CSIC, CIQSO-Centro de Investigación en Química Sostenible and Departamento de Química, Universidad de Huelva, Campus de El Carmen, 21007, Huelva, Spain. perez@dqcm.uhu.es.
Soluble gold (Au) complexes catalyze carbene group transfer from diazo compounds to organic molecules. This review highlights recent advances in gold catalysis, providing a foundation for future developments.
Area of Science:
- Organometallic Chemistry
- Catalysis
- Organic Synthesis
Background:
- Discovery of soluble gold (Au) complexes in 2005 revolutionized carbene transfer reactions.
- Carbene transfer is crucial for synthesizing complex organic molecules.
Purpose of the Study:
- To review recent advances in gold-catalyzed carbene transfer reactions.
- To provide a foundation for future research and development in this field.
Main Methods:
- Review of literature on gold-catalyzed carbene transfer.
- Analysis of reported transformations and catalytic mechanisms.
Main Results:
- Significant increase in reported gold-catalyzed carbene transfer reactions since 2005.
- Demonstration of the versatility of soluble Au complexes in various organic transformations.
Conclusions:
- Gold catalysis offers a powerful and efficient method for carbene group transfer.
- The field is rapidly evolving, with substantial potential for new discoveries and applications.
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