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Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells
Published on: October 13, 2023
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POLE proofreading mutation, immune response and prognosis in endometrial cancer
Inge C van Gool1, Tjalling Bosse1, David N Church2
1Department of Pathology, Leiden University Medical Center , Leiden, the Netherlands.
Oncoimmunology
|May 4, 2016
Abstract:
Endometrial cancers (ECs) with POLE proofreading mutations are typified by ultramutation and excellent prognosis. We investigated whether these were related, and found that POLE-mutant ECs display a robust T cell response that corresponds to an enrichment of antigenic tumor neopeptides. Enhanced immunogenicity may explain the favorable outcome of POLE-mutant ECs.

